Data Warehouse for Systemic Toxicity

ToxBank Data WarehouseThe ToxBank Data Warehouse is establishing a centralised compilation of data for systemic toxicity.

Data generated under the research program and additional public data is uploaded and integrated whenever possible into computerised models capable of predicting repeated-dose toxicity.

The ToxBank data warehouse uses the ISA-TAB file format for interchange, storage and query of any investigation data, including dose-response and omics results.

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The aim of the SEURAT-1 (Safety Evaluation Ultimately Replacing Animal Testing-1) research cluster, comprised of seven EU FP7 Health projects co-financed by Cosmetics Europe, is to generate a proof-of-concept to show how the latest technologies, systems toxicology and toxicogenomics can be combined to deliver a test replacement for repeated dose systemic toxicity testing on animals.

The SEURAT-1 strategy is to adopt a mode-of-action framework to describe repeated dose toxicity, combining in vitro and in silico methods to derive predictions of in vivo toxicity responses. ToxBank is the cross-cluster infrastructure project whose activities include the development of a data warehouse to provide a web-accessible shared repository of research data and protocols, a physical compounds repository, reference or “gold compounds” for use across the cluster (available via, and a reference resource for biomaterials.

Core technologies used in the data warehouse include the ISA-Tab universal data exchange format, REpresentational State Transfer (REST) web services, the W3C Resource Description Framework (RDF) and the OpenTox standards. We describe the design of the data warehouse based on cluster requirements, the implementation based on open standards, and finally the underlying concepts and initial results of a data analysis utilizing public data related to the gold compounds.