The ToxBank Gold Compound Database will provide a high quality information resource servicing the selection and use of test compounds.
Chemicals in this database will be supported by high-quality-repeated-dose toxicity in vivo and in vitro data, property data and, whenever available, human adverse event and epidemiological data. Selected test compounds for training or validation, and standard operating procedures for data quality control, processing and analyses will be provided.
These reference compounds will form a “gold standard”.
The goal for the Gold Compounds Working Group (GCWG) is to achieve consensus across SEURAT-1 program stakeholders on the criteria for selecting, accepting and using test substances in the development of alternative testing methods for systemic toxicity.
Cross-project members and additional external experts collaborate on the discussion of compound selection, mechanisms and assays. In order to support early development and testing work carried out on the program projects, a preliminary short list of test compounds was established in collaboration with the other projects in 2011 and was further developed in 2012.
A criterion for these compounds is a preference for previously well-studied compounds for which a good understanding of mechanisms of action for phenomenon such as cholestasis and phospholipidosis exist.